Nota Biografica

STEFANO BARABINO

EDUCATION
1991 Diploma, Liceo Scientifico Saccheri, Sanremo, Italy 1998 Doctor of Medicine (MD), Università di Genova, Genoa, Italy 2006 Philosophical Doctorate (PhD) in Immunology, Università di Genova, M.D., Ph.D., Associate Professor of Ophthalmology Postdoctoral Training: Internship and Residency 1998-1999 Intern in Medicine, Ospedale San Martino, Genoa, Italy 1999-2003 Resident in Ophthalmology, Università di Genova Clinical and Research Fellowship 2001 Fellow, Corneal & External Diseases, Kyoto Prefectural University, Kyoto, Japan (ref: Prof. Shigeru Kinoshita, shigeruk@ophth.kpu-m.ac.jp) 2003-2005 Fellow, Ocular Surface & Immunology, Schepens Eye Research Institute, and Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, USA (ref: Prof. Reza Dana, reza_dana@meei.harvard.edu) Licensure and Certification: 1998 Italian and European Community medical license 2002 Diplomate, Italian Board of Ophthalmology 2014 Associate Professor of Ophthalmology, Italian Minister of University and Research (MIUR) Academic Appointments: 2005-2010 Instructor, Università di Genova 2010-2014 Assistant Professor of Ophthalmology, Università di Genova 2014- Associate Professor of Ophthalmology Hospital Service Responsibilities: 2002-2005 Clinical Associate, Cornea/External disease and Ocular Immunology, Clinica Oculistica, Università di Genova 2005- Associate Director, Cornea/External disease and Ocular Immunology, Clinica Oculistica, Università di Genova.

LICENSURE AND CERTIFICATION:
1998 Italian and European Community medical license 2002 Diplomate, Italian Board of Ophthalmology 2014 Associate Professor of Ophthalmology, Italian Minister of University and Research (MIUR) Academic Appointments: 2005-2010 Instructor, Università di Genova 2010-2014 Assistant Professor of Ophthalmology, Università di Genova 2014- Associate Professor of Ophthalmology Hospital Service Responsibilities: 2002-2005 Clinical Associate, Cornea/External disease and Ocular Immunology, Clinica Oculistica, Università di Genova 2005- Associate Director, Cornea/External disease and Ocular Immunology, Clinica Oculistica, Università di Genova. Responsible for staff: 3 residents, 4 optometrists, 1 postdoctoral fellow, 2 graduate students. Technologies: OCT, confocal microscopy, impression cytology, cell and tears immune-analysis, ferning test, osmometer, evaporimeter, corneal topography, endothelial cell count. Surgery: ocular surface reconstruction, refractive surgery, limbal stem cells transplantation, amniotic membrane transplantation. Contactology. 2014- Director, Cornea/External disease and Ocular Immunology, Clinica Oculistica, Università di Genova 2002- Clinical Associate, Glaucoma Service, Clinica Oculistica, Università di Genova, Responsible for staff: 2 residents, 3 optometrists, 1 postdoctoral fellow, 2 graduate students

TECHNOLOGIES:
OCT, HRT, visual field tests. Report of Clinical Activities In addition to full-time hospital-based activities, I am involved in clinical research in the areas of ocular surface and ocular inflammatory diseases. I have established interdisciplinary collaborations with Rheumatology (for autoimmune diseases) and Hematology (for graft-versus-host cases), and I have recently expanded the translational and clinical activities of the Cornea Service by creating a Translational Research Group, an Ocular Surface Imaging Center, and a section of Contactology. Professional Societies: 1999- Member,Association for Vision and Research in Ophthalmology (ARVO) 2000-2002 International Ocular Surface Society (IOSS) 2000- Member, Italian Ophthalmology Society (SOI) 2003-2006 Member, American Academy of Ophthalmology (AAO) 2000 Member, Tear Film and Ocular Surface Society (TFOS) 2002-2008 Co-Chair Associate Advisory Board, Tear Film and Ocular Surface Society (TFOS) 2009-2013 Member of the Advisory Board, Tear Film and Ocular Surface Society (TFOS) 2008- Member of the Advisory Board, Italian Dacriology and Ocular Surface Society (SIDSO) 2015- Member of the Advisory Board, Italian Society of Day Surgery (ADSI)

PUBBLICAZIONI SELEZIONATE
2011- Editorial Board Member, The Ocular Surface 2013- Editorial Board Member Eye and Contact Lens 2014- Editorial Board Member Ocular Immunology & Inflammation 2014- Editorial Board Member BMC Ophthalmology 2000- Ad hoc Reviewer, Ophthalmology, The American Journal of Clinical Nutrition Investigative Ophthalmology & Visual Science Current Eye Research, Survey of Ophthalmology, Ophthalmic and Physiological Optics, Cornea, Journal of Optometry and Vision Science, Ocular immunology & Inflammation, Graefe’s Archive of Clinical and Experimental Ophthalmology, European Journal of Ophthalmology, The Ocular Surface Awards and Honors: 1999 Rotary Youth Leadership Award, Turin, Italy 1998 Bruschettini Award, Italian Ophthalmology Society, Rome, Italy 1999 Travel grant, European Vision and Eye Research Society (EVER), Palma de Mallorca, Spain 2000 Travel grant, The Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, USA 2001 Best Young Investigator Research Project, Università di Genova, Genoa, Italy 2003 Travel grant, Università di Genova, Genoa, Italy 2003 Rotary International Ambassadorial Scholarship Award, Chicago, IL 2002 Research grant, Fondazione Cassa di Risparmio di Genova e Imperia, Genoa, Italy 2004 Research grant, Massachusetts Eye & Ear Infirmary, Boston, MA 2009 Travel grant, Tear Film and Ocular Surface Society (TFOS), Portoroz, Slovenia 2009 Award, Italian Ophthalmology Society, Milan, Italy 2010 Award, North Italian Ophthalmology Society, Castellaro (IM), Italy 2011 Best Scientific Paper, European Society of Cataract and Refractive Surgeons (ESCRS), Wien, Austria. Invited Talks (International): 2000 Advances in Medical and Surgical Therapies for Ocular Surface Diseases, International Conference, Santa Margherita Ligure, Italy “Amniotic membrane” Advances in Medical and Surgical Therapies for Ocular Surface Diseases International Conference, Santa Margherita Ligure, Italy “Ocular surface reconstruction” 2001 European Ohthalmological Society, Istanbul, Turkey “Use of systemic linoleic and gamma-linolenic acid therapy for dry eyes” Invited Speaker Santen Pharmaceutical Company, Kyoto, Japan “Use of systemic linoleic and gamma-linolenic acid therapy for dry eyes” 2002 Invited Speaker First European Meeting “Advances in diagnosis and treatment of ocular surface diseases”, Santa Margherita Ligure, Italy “Advances on amniotic membrane transplantation for ocular surface reconstruction” 2004 Tear Film and Ocular Surface Society (TFOS) Meeting, Puerto Rico, USA “The controlled environment chamber: a new mouse model for dry eyes” 2005 Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, USA “Exposure to a dry environment induces strain-specific dry eye in mice” 2006 Invited Speaker 6th International Symposium on Ocular Pharmacology and Therapeutics (ISOPT), Berlin, Germany, “Animal models of dry eye” 2007 Tear Film and Ocular Surface Society (TFOS) Meeting, Taormina, Italy “Ocular surface inflammation and corneal changes in patients with cicatricial pemphigoid” 2008 Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, USA Organizer and moderator of the Special Interest Group (SIG) “Ocular surface inflammation in dry eye: what is hype and what is real?” 2009 TRB Chemedica International satellite symposium, Amsterdam, Holland Chairman and speaker “ Benefits of hypotonic eye drop formulations” Invited speaker European Association for Vision and eye Research (EVER), Portoroz, Slovenia “Pathological alterations in Meibomian gland dysfunction as an important factor in ocular surface disease” Invited speaker satellite roundtable of the American Academy of Ophthalmology, San Francisco, USA “Prevalence of ocular surface disease in glaucoma patients” Invited speaker International Symposium on Ocular Pharmacology and therapeutics (ISOPT), Rome “Lymphocytes detection on the ocular surface of dry eye patients” 2010 Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, USA Organizer and moderator of the Special Interest Group (SIG) “The role of Ocular surface inflammation in dry eye” TRB Chemedica International satellite symposium of the World Ophthalmology Conference, Berlin, Germany, Chairman and speaker “ Benefits of hypotonic hyaluronic acid lubricant eye drops in dry eye” Invited speaker World Ophthalmology Congress (WOC), Berlin, Germany “New treatments for Meibomian gland diseases” Invited speaker World Ophthalmology Congress (WOC), Berlin, Germany “Immune response in conjunctival epithelium of dry eye patients” Tear Film and Ocular Surface Society (TFOS), Florence, Italy, “Immune response in the conjunctival epithelium and ocular surface damage in patients with dry eye” Tear Film and Ocular Surface Society (TFOS), Florence, Italy, “Global treatments for dry eye syndrome: an unmet need”, closing remarks Invited speaker, Bumrungrad Hospital, Bangkok, Thailand “Update on cornea and ocular surface” Invited speaker, The Royal College of Ophthalmologists of Thailand meeting, Bangkok, Thailand “Osmolarity: pivotal role for treatment of dry eye and ocular surface damage”, “New knowledge on dry eye: from research to clinical practice” Invited speaker, The Royal Society of Medicine, London, UK “Management of MGD” 2011 Invited speaker, Seventh Polish Glaucoma Symposium, Wroclaw, Poland, “The effect of chronic instillation of preservatives on the ocular surface in glaucoma patients” Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, USA Organizer and speaker of the Special Interest Group (SIG) “To do or not to do: does an anti-inflammatory approach in dry eye disease make sense? European Cornea Society (Eucornea), Vienna, Austria “A pilot double blind comparative clinical trial to evaluate the effect of an artificial tear containing hyaluronic acid and tamarind seeds polysaccharide in patients with moderate dry eye syndrome” Invited speaker, Spanish Ophthalmology Society, Oviedo, Spain “Impacto de la DGM en clinica y en cirugia. Tratamiento” Invited speaker, Controversies in Ophthalmology, Warsaw, Poland “The effect and complications of chronic instillation of preservatives on the ocular surface in glaucoma patients” 2012 Invited speaker, Portuguese Ocular Inflammation Group, Unhais da Serra, Portugal, “DGM- Implicacoes clinicas e cirurgicas” Invited speaker, World Ophthalmology conference (WOC), Abu Dhabi,United Arab Emirates, “ Refractive surgery-induced dry eye” Invited speaker, World Ophthalmology conference (WOC), Abu Dhabi,United Arab Emirates, “ Cataract surgery-induced dry eye” Invited speaker, World Ophthalmology conference (WOC), Abu Dhabi,United Arab Emirates, “ Dry eye: is it a true inflammatory disease of the ocular surface?” Chairman and speaker, World Ophthalmology conference (WOC), Abu Dhabi, United Arab Emirates, “ Immune cells on the ocular surface of dry eye patients and the effect of topical anti-inflammatory treatment”. Guest speaker, Dry Eye Conference, Riyadh, Saudi Arabia “The latest science on dry eye management”. Guest speaker, Dry Eye Conference, Khobar, Saudi Arabia “The latest science on dry eye management” Invited lecturer Hanoi and Ho Chi Min Hospital, Vietnam, “Dry eye syndrome” Invited lecturer, Kuala Lumpur, Malaysia “Dry eye syndrome” 2013 Guest speaker, Cornea Infectious Disesase Conference, Beirut, Lebanon “A new antibiotic” Guest speaker, Dry Eye Symposium, Jordan and Kuwait, “The latest science on dry eye management” Invited speaker, Dry Eye and Contact lens update meeting, Berlin, Germany “Highlights from ARVO on dry eye”, Berlin, Germany Invited speaker, Dry Eye Meeting, Singapore “Dry eye, its link to other eye diseases and the way to manage” Invited speaker , White Nights conference, San Petersburg, Russia, “New knowledge on dry eye: from research to clinical practice”, Invited speaker, Russian Society of Ophthalmology Annual Conference, Moscow, Russia, “What is dry eye and how can we treat it?”, Guest speaker, Dry Eye Symposium, Doha, Qatar “The latest science on dry eye management” 2014 Invited Speaker, Singapore National Eye Center, Singapore “Ocean report on pathogenesis and management of dry eye” Invited speaker, Regional Ophthalmology Congress, Kuala Lumpur, Malaysia “Understanding the depth of ocean” Invited speaker, Regional Ophthalmology Congress, Kuala Lumpur, Malaysia “Are we treating lipid deficiency dry eye adequately?” Invited speaker, International Society of Ocular Pharmacology and Therapeutics (ISOPT), Reykjavik, Iceland “The Role of Ocular Surface Epithelia in Dry Eye Syndrome” Invited speaker, Dry Eye Specialists’ Roundtable Meeting, Orlando, USA Invited speaker, Russian Society of Ophthalmology Annual Conference, Moscow, Russia “The interaction between contact lens and ocular surface” 2015 Invited speaker, European Society Cataract Refractive Surgery (ESCRS) Satellite Meeting, Istanbul, Turkey “Dry eye Treatment” Invited speaker, Alcon Meeting, Dubai and Abu Dhabi “The interaction between the ocular surface and contact lens” Invited speaker, French American Ophthalmology Symposium, Monaco “New perspectives in dry eye syndrome” Instructional Course European Society Cataract Refractive Surgery (ESCRS), Barcelona, Spain Organizer and speaker “Understanding and managing dry eye after cataract and refractive surgery” Instructional Course European Society Cataract Refractive Surgery (ESCRS), Barcelona, Spain Organizer and speaker “Tablet and smartphone application in Ophthalmology” European Society Cataract Refractive Surgery (ESCRS), Barcelona, Spain Moderator “Current and future indications of omega-3 fatty acids for ocular surface diseases” Invited speaker, University of Lausanne, Lausanne, Switzerland “Ocular Allergy” 2016 Invited speaker, Tear film and Ocular Surface Society (TFOS)- Santen symposium, Montpellier (France) “Targeting inflammation: pathogenesis and novel treatments for dry eye” Tear Film and Ocular Surface Society (TFOS), Montpellier (France) Moderator “Unique challenges and unmet needs for the treatment of ocular surface disease in various regions of the world” Invited speaker, Santen dry eye symposium for Asian doctors, Montpellier (France) “Dry eye treatment in Europe” Instructional Course European Society Cataract Refractive Surgery (ESCRS), Copenhagen, Denmark Organizer and speaker “Understanding and managing dry eye after cataract and refractive surgery” 2017 Invited speaker, Santen event, Hanoi and Saigon, Vietnam “How to overcome dry eye treatment with Cationorm Invited Talks (national) From 1999 to today I have been invited as speaker to more than 60 national conferences. Pre- Clinical Research Experience In 2003 I developed a mouse model of dry eye (Barabino et al., The controlled environment chamber: a new mouse model for dry eyes. Invest Ophthalmol Vis Sci 2005;46:2766-2771) that has been used to study dry eye pathogenesis and to test numerous treatments for dry eye. Clinical Research Experience: 1998- Investigator in 21 clinical studies at Clinica Oculistica, Department of Ophthalmology, Neurosciences, and Genetics, Università di Genova 2002- Coordinator and principal investigator in 7 clinical studies at Clinica Oculistica, Department of Ophthalmology, Neurosciences, and Genetics, Università di Genova Scientific innovations: Patents 1. Composizioni oftalmiche a base di acidi grassi polinsaturi omega-3 e omega-6, patent pending: RM2009A000119 2. Ophthalmic composition based on polyunsatured omega-3 and omega-6 fatty acids, Application n./patent n.: 10717302.3-1219 PCT/IT 2010000119. Others 1. A new mouse model of dry eye (Barabino S, et al. The controlled environment chamber: a new mouse model for dry eyes. Invest Ophthalmol Vis Sci 2005;46:2766-2771) 2. IEYES, a new app for ipad and iphone to record patients data with specific sections for glaucoma and ocular surface diseases that can be used in every clinical setting and to run clinical studies (presented at ARVO and at next ESCRS meeting in 2015)